The following images attempt to illustrate
the major complexes and events involved in protein trafficking from the rough endoplasmic reticulum, through the Golgi apparatus. Clicking on each of the
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see the Flash movie for the following sequence of images,
In the first stage of protein trafficking, translated proteins from the rough endoplasmic reticulum are carried to the Golgi apparatus by vesicles.
Once the proteins reach the Golgi, they are modified by specific enzymes.
According to the cis-maturation model, proteins are carried through the appartus as the cisternae they reside in migrates from the cis to the trans side of the Golgi stack.
Once they reach the trans Golgi network (TGN), proteins are again packaged into vesicles and distributed elsewhere to their final destination.